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In fact, a 12 week cycle of RAD 140 may give similar mass gain results as a mild dose of testosterone enanthate. In a 12 week cycle, RAD 140 is only 3.9% of total testosterone, but is more effective at reducing the rate at which testosterone is converted to dihydrotestosterone. In these women, RAD 140 is not superior to testosterone at lowering dihydrotestosterone to undetectable levels compared to other hormones. In addition, RAD 140 has also been shown to provide a modest advantage compared to testosterone cypionate when given in combination with tamoxifen therapy.17-23 Therefore, while much more research is needed before any recommendations can be made about the use of RAD 140 as a sexual performance enhancer, it is an attractive potential tool for certain women with hypogonadism. Although there is no clear evidence that RAD 140 is an effective alternative to testosterone in this condition, it may be of interest to research clinicians. One additional concern, which can be alleviated with appropriate management, is the risk of adverse reactions to a regimen that has been shown to be effective in treating hypogonadism. Some studies have shown that the incidence of adverse reactions to testosterone replacement is similar among persons taking other testosterone products as compared to those taking the combination of testosterone cypionate and RAD 140.24,25 The most noticeable adverse reactions with RAD 140 use include: headache, fatigue, acne, and prostate enlargement. Other possible adverse reactions include gastrointestinal (gastrointestinal disturbances, nausea, rash, gastrointestinal bleeding, and urinary tract infection), respiratory, and liver/thyroid problems. Although there is an increased risk of adverse reactions when a medication is started in the early stage, including severe nausea/vomiting, these reactions become less common as drug effectiveness increases. Thus, the possibility of adverse reactions occurring in patients who have previously been prescribed a testosterone-based therapy, as may occur with RAD 140, is important to evaluate. Despite the concerns regarding the treatment of hypogonadism, it is important to recognize that men who are men deserve our health. The use of hormone replacement therapy is currently a reasonable approach for those men concerned with maintaining health. With a full course of hormone therapy, the risk of future adverse reactions from the combination of testosterone and RAD 140 decreases significantly, especially when considering the risk of bleeding, which decreases from 40% to less than 8%, while the frequency of side effects increases from 3-4% to approximately 20%. With proper patient counseling, the risk of complications, such as anemia, may be minimized. REFERENC Similar articles: